Relative in vitro stability of ornithine decarboxylase from liver preneoplastic nodules and hepatomas.
نویسندگان
چکیده
A very rapid and drastic microsome-dependent in vitro inactivation of the hydrocortisone-induced ornithine decarboxylase in rat liver was reported recently (M. F. Zuretti and E. Gravela, Biochim. Biophys. Acta. 742: 269-277, 1983). Present results show that ornithine decarboxylase from preneoplastic nodules and hepatomas, which have been induced in rats by N-2-fluorenylacetamide, is much more stable, its greater stability not being accounted for by a lower microsome-bound inactivating capacity. The possibility of a relationship between the in vitro enzyme stability and the increase of enzyme activity in neoplastic tissues is suggested.
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ورودعنوان ژورنال:
- Cancer research
دوره 43 5 شماره
صفحات -
تاریخ انتشار 1983